Biochemical, pharmacological, and toxic effects of n-metil 3,4-methylenedioxyamphetamine - "ecstasy"
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چکیده
منابع مشابه
Isotopic characterisation of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethylamphetamine (ecstasy).
Combined delta2H, delta13C and delta15N isotopic analysis of MDA and MDMA extracted from seized "ecstasy" tablets provides an isotopic "fingerprint" of the active ingredient allowing individual tablets to be linked to a common batch. Correlating these data with 2H NMR analysis of the extracts has the potential to study both the natural precursor materials and synthetic pathways used in the prep...
متن کامل[Ecstasy: a pharmacological review].
A literature review on 3,4 methylenedioxymethanphetaneine (MDMA), known as ecstasy, a drug with increased use among youngsters is presented. The history from its synthesis, up to its use as an adjunct to psychotherapy and, more recently, as a drug of abuse, is described. The possible pattern of abuse in several countries is reviewed with the objective of predicting what might happen in Brazil, ...
متن کاملMajor metabolites of (+/-)3,4-methylenedioxyamphetamine (MDA) do not mediate its toxic effects on brain serotonin neurons.
The two major metabolites of (+/-)3,4-methylenedioxyamphetamine (MDA), alpha-methyldopamine (alpha-MeDA) and 3-O-methyl-alpha-methyldopamine (3-O-Me-alpha-MeDA), were administered to rats intracerebroventricularly and into brain parenchyma. In addition, their precursors, (alpha-MeDOPA and 3-O-Me-alpha-MeDOPA, respectively) were administered systemically, individually and in combination. None of...
متن کاملPharmacological interaction between 3,4-methylenedioxymethamphetamine (ecstasy) and paroxetine: pharmacological effects and pharmacokinetics.
3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") is increasingly used by young people for its euphoric and empathic effects. MDMA can be used in combination with other drugs such as selective serotonin reuptake inhibitors. A clinical trial was designed where subjects pretreated with paroxetine, one of the most potent inhibitors of both 5-hydroxytryptamine reuptake and CYP2D6 activity, were c...
متن کاملPharmacological and toxic effects of kryptopyrrole in mice.
Preliminary findings indicate that patients with acute intermittent porphyria excreted increased amounts of urinary kryptopyrrole during acute attacks associated with neuropsychiatric symptoms (Irvine and Wetterberg, 1971). These symptoms of acute porphyria are of special interest since they are sometimes of schizophrenic type (Waldenstrom, 1937; Peters, 1962) or constitute a porphyria mental s...
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ژورنال
عنوان ژورنال: Military Medical and Pharmaceutical Journal of Serbia
سال: 2005
ISSN: 0042-8450,2406-0720
DOI: 10.2298/vsp0506467m